Mortality Statistics: 1905

Differences among official statistics of mortality rates in Iran

Dear Editor, Death indicators and causes of death are both closely associated with socio-cultural, economic, and structural factors and determinants of health, with all of which being at the core of the planning, monitoring, and assessment of intervention programs in any healthcare system (1). In Iran, the diagnosis and official registration of deaths are carried out by two independent organiz...

Dmd059121 1890..1905

Subcutaneous injection is an important route of administration for therapeutic proteins that provides several advantages over other modes of parenteral delivery. Despite extensive clinical use, the exact mechanism underlying subcutaneous absorption of proteins is not completely understood, and the accuracy of prediction of absorption of biotherapeutics in humans remains unsatisfactory. This rev...

Dmd065763 1905..1916

Montelukast has been recommended as a selective in vitro and in vivo probe of cytochrome P450 (P450) CYP2C8 activity, but its selectivity toward this enzyme remains unclear. We performed detailed characterization of montelukast metabolism in vitro using human liver microsomes (HLMs), expressed P450s, and uridine 59-diphospho-glucuronosyltransferases (UGTs). Kinetic and inhibition experiments pe...

Phoebus A. Levene, 1905

Mark's Annual Reports, 1905